منابع مشابه
Capturing Pluripotency
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-r...
متن کاملHuman pluripotency
Pluripotent cells have unique properties of self-renewal while maintaining developmental potential to differentiate into all three germ layers. By definition, pluripo-tent cells have no predetermined lineage program, thereby forming the fundamental basis of enquiry and experimental investigations to understand cell fate decisions. Molecular and cellular insights into human pluripotent stem cell...
متن کاملPluripotency and nuclear reprogramming.
Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be ove...
متن کاملSplicing up Pluripotency
In this issue of Cell, Gabut and colleagues (2011) identify a new splice variant of FOXP1 that directly regulates the expression of pluripotency genes. It endows human embryonic stem cells with their pluripotent nature and is required for the reprogramming of somatic cells to induced pluripotent stem cells.
متن کاملStress and pluripotency
Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al., 2014a,b). The findings were controversial, and the authors have now retracted the papers, citing multiple critical errors within the reports that impaired the credibility of the findings ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2010
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2980